Moreover, since VGF has diverse roles in the hippocampus, including learning and memory [1,45,46], and is associated with impaired memory and Alzheimer’s Disease [11,12,66,67], it will also be important in future studies to explore the role of the VGF SNPs in neurodegenerative diseases as has been done for Val66Met BDNF polymorphism [68,69]. Here, VGF is linked to early-onset autosomal dominant Alzheimer disease.