EZH2 and cardiac hypertrophy: Mechanistically, a 66-mer motif in Chaer can directly interact with the enhancer of zeste homolog 2 (EZH2) subunit of polycomb repressor complex 2 (PRC2), and interfere with PRC2 targeting to genomic loci, thereby inhibiting histone H3 lysine 27 methylation in the promoter regions of cardiac hypertrophy-associated genes.