In Ang II-induced hypertensive mice, cardiac hypertrophy related lncRNA named CHRF can inhibit the expression and activity of miR-489 as an endogenous molecular sponge, and subsequently up-regulate the level of myeloid differentiation factor88 (MyD88), which is a direct target of miR-489, to promote cardiac hypertrophy [36]. The gene discussed is AGT; the disease is cardiac hypertrophy.