Regarding the tumor extent, high Ki-67 expression was associated with poor OS (HR 2.01; 95% CI: 1.46–2.77; p < 0.001) and CSS (HR 1.80; 95% CI: 1.52–2.31; p < 0.001) but not with DFS (HR = 2.11; 95% CI: 0.74–6.50; p = 0.178) for all stages of RCC; with poor DFS (HR = 2.63; 95% CI: 1.79–3.85; p < 0.001) but not with OS (HR 1.40; 95% CI: 0.52–3.76; p = 0.504) and CSS (HR = 2.29; 95% CI: 0.85–6.19; p = 0.104) for localized RCC; and with poor CSS (HR = 1.49; 95% CI: 1.22–1.82; p < 0.001) for metastatic RCC. The gene discussed is MKI67; the disease is neoplasm.