HMGB1 and chronic obstructive pulmonary disease: In a COPD GWAS dataset8, nominal association with case-control status was observed for SNPs annotated to BCL2 (rs1481031, p = 0.0003), BCL11A (rs191541310, p = 0.007), POU2AF1 (rs2282637, p = 0.008), HMGB1 (rs117938771, p = 0.01), and SERPINE2 (rs6721140, p = 0.03).