HGF and neoplasm: The afatinib/trametinib combination was the optimal constant strategy for tumor cell populations harboring the EGFRL858R, T790M mutation, and although this strategy invoked progression free response in HGF− tumor cell populations, most EGFRL858R HGF+ tumor cell populations progressed on the therapy over thirty days (Fig. 4A vs 4C and Fig. S7AB).