Native full-length ANGPTL4 (fANGPTL4) is proteolytically cleaved into two functionally distinct isoforms: the N-terminal domain (nANGPTL4) inhibits lipoprotein lipase (LPL) and directly regulates energy homeostasis, while the C-terminal domain (cANGPTL4) has been implicated in various processes such as cancer metastasis, skin wound and pulmonary inflammation6, 7, 8. Here, ANGPTL4 is linked to cancer.