TRPV1 and type 1 diabetes mellitus: In conclusion, this study suggests that: i) neurovascular responses at the forearm level are impaired in T1D patients without impairment of the ACh and SNP responses compared with matched control-subjects; ii) microvascular response mediated by TRPV-1 channels is diminished; and iii) neurovascular abnormalities appears earlier than other microvascular abnormalities.