RHOA and orofacial cleft: ARHGAP29 inactivates RhoA (ref. 37) and RhoA regulates keratinocyte migration38, 39; gain and loss-of-function experiments have shown that ARHGAP29 positively regulate oral keratinocyte migration in vitro, while mutant ARHGAP29 identified in orofacial clefting patients is unstable and fails to accelerate cell migration40.