ARHGAP29 inactivates RhoA (ref. 37) and RhoA regulates keratinocyte migration38, 39; gain and loss-of-function experiments have shown that ARHGAP29 positively regulate oral keratinocyte migration in vitro, while mutant ARHGAP29 identified in orofacial clefting patients is unstable and fails to accelerate cell migration40. The gene discussed is ARHGAP29; the disease is orofacial cleft.