In the course of investigating the function of ELF5 in PCa progress, we discovered downregulation of ELF5 in stably selected ELF5 knockdown cells (infected by shRNAs for ELF5, shELF5) potently stimulated the viability of human PCa LNCaP and VCaP cells (Fig. 1A). This evidence concerns the gene ELF5 and posterior cortical atrophy.