EGFR and neoplasm: We expect that a combination of brigatinib and anti-EGFR antibody would improve sensitivity to the triple-mutant EGFR, resulting in better efficacy as shown in our study of the long-term tumour stability in PC9 triple-mutant xenografts and significant tumour shrinkage in MGH121-res2 xenografts; this implies that long-term ‘stable disease' or ‘partial response' was achieved with the combination therapy, whereas only the inhibition of tumour growth was attained with brigatinib monotherapy.