EGFR and lung carcinoma: Jänne et al. 30 reported that in a phase 1/2 trial of osimertinib, among 127 patients with confirmed EGFR T790M who could be evaluated, the response rate was 61% and the median progression-free survival was 9.6 months, which is as long as that of first-line EGFR–TKIs for EGFR-mutated lung cancer.