Our study showed an association between IgE and IL-6 in sera of SLE patients with RF+IgE+ (r2 = 0.583, P = 0.027, Figure 3); the IgE also correlated with IL-1β (r2 = 0.567, P = 0.031, Figure 4); the IL-6 level correlated with IL-1β levels (r2 = 0.847, P = 0.001, Figure 5). The gene discussed is IGHE; the disease is systemic lupus erythematosus.