Thus, patients with congenital FXI deficiency are protected from venous thromboembolism (VTE) and ischemic stroke, subjects with higher levels of FXI are at greater risk for VTE and ischemic stroke than those with lower levels, and the levels of FXI correlate with stroke risk in women taking oral contraceptives (19, 20). The gene discussed is F11; the disease is hyperinsulinemic hypoglycemia, familial, 4.