MECP2 and atypical Rett syndrome: A few cases of type 1 diabetes have been associated to Rett syndrome, but the number of cases is still too low to determine whether this is mere serendipity or if they were caused by MeCP2 mutations and downstream REST activity (Kurtoglu et al., 2005; Rekik et al., 2010; Akin et al., 2012).