REST and ischemia: De-repression of REST in neurons has also been shown to occur in response to ischemia, leading to down-regulation of REST target genes, notably the GRIA2 subunit of the glutamate receptor regulating Ca2+ permeability and miR-29c, that promoted neuronal death (Calderone et al., 2003; Noh et al., 2012; Pandi et al., 2013).