Furthermore, in the same paper, Goumy et al. [318] suggested that a similar phenomenon occurs in the mouse when taking into account the spina bifida phenotype seen on the Splotch mouse that is affected by both Pax3 [93] and EphA4 [319], albeit the link between the two in the mouse has yet to be ascertained. This evidence concerns the gene EPHA4 and spina bifida.