Corresponding numbers for DCIS with crushed stone calcifications were HER2+/ER− lesions in 18%, HER2−/ER− lesions in 7%, and ER+ lesions in 75% of the cases and for DCIS with architectural distortion they were HER2+/ER− lesions in 8%, HER2−/ER− lesions in 19%, and ER+ lesions in 73%. Here, ESR1 is linked to ductal breast carcinoma in situ.