Our study also observed no correlation between BMI and serum estradiol (r = 0.124, p = 0.39) or LH (r = 0.04, p = 0.77), despite the presence of a significant negative correlation between BMI and serum testosterone (r = −0.306, p = 0.034), which also suggests that aromatisation is unlikely to be the dominant cause for obesity related hypogonadism. Here, PLOD1 is linked to obesity due to melanocortin 4 receptor deficiency.