Molecular mechanisms have elucidated the ability of Jun-B to function as a cell cycle inhibitor and tumor suppressor gene via down-regulation of cyclin D expression and up-regulation of p16INK4A expression as a tumor suppressor inhibiting CDK4 and CDK6 genes.39,40 CDK6 was enriched in PPI network in the present study. The gene discussed is CDK4; the disease is neoplasm.