Another type of molecules able to block the activity of ErbB proteins is tyrosine kinase inhibitors (TKI): gefitinib (Iressa), erlotinib (Tarceva), and lapatinib; the first two target the tyrosine kinase domain of EGFR with activating mutation (L747-S752 deletion) and are approved for clinical applications in NSCLC [62–64]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.