In another study using SK-BR-3 human breast cancer cell line and COS7 monkey fibroblasts transiently transfected with ErbB2, curcumin downregulated ErbB2 protein by ubiquitination through chaperone-dependent ubiquitin ligase, carboxyl terminus of HSP70-interacting protein (CHIP) [97]. The gene discussed is ERBB2; the disease is breast cancer.