ERBB2 and neoplasm: The first one is able to bind to the IVth region of the extracellular domain of the protein and to trigger antibody-dependent cellular cytotoxicity (ADCC) by attracting the immune cells to the tumor site, while the second one recognizes the dimerization arm of ErbB2 protein being able to block the dimerization process [5, 7, 8, 38].