C-terminally cleaved TDP-43 fragments are another pathological hallmark of ALS and FTD, and expression of TDP-43 in cell culture models can give rise to cleavage products of 35 and 25 kDa in the absence or presence of various stressors (Neumann et al., 2006; Hasegawa et al., 2008; Chiang et al., 2012; Yang et al., 2014; Li et al., 2015). Here, TARDBP is linked to amyotrophic lateral sclerosis.