To determine whether the effect of avermectins on Aβ production was specific to the TS21 genotype, or whether avermectins could alter APP processing in other genetic forms of AD, we tested selamectin in cortical neurons derived from iPSCs from a healthy control (non-diseased control [NDC]), and patients carrying an APP duplication (APPdup), an APP missense mutation (APP V717I), or a Presenilin-1 mutation (PSEN1 M146I) (Figure 7B). The gene discussed is PSEN1; the disease is Alzheimer disease.