IL6R and type 1 diabetes mellitus: Previously, a genetic variant in IL6R (rs2228145 A > C; Asp358Ala) has been associated with human inflammatory diseases, including T1D [38], ankylosing spondylitis [39] and rheumatoid arthritis [40], presumably due to a greater expression of the IL-6 receptor and therefore a higher IL-6 signalling capacity in CD4+ Teffs expressing the common Asp358 susceptibility allele compared to Ala358 [38].