IL10 and infection: Our observation that IL-10 is expressed at high levels by IL-6RhiTIGIT− mTregs, suggests that they represent a major IL-10-producing Treg subset in humans, and play a critical role in the regulation of the IL-17-mediated immune responses at the sites of infection, which is key to maintain the homeostasis between commensal bacteria and invading pathogens at mucosal barrier surfaces.