Significantly increased levels of the cytokine TNF-α (P ≤ 0.001) and the chemokines CCL5 (P ≤ 0.01) and CXCL-1 (P ≤ 0.0001) were found in infected 3xTg-AD mice compared to infected Non-Tg mice. This evidence concerns the gene TNF and Alzheimer disease.