Following E/S stimulation, infected 3xTg-AD mice produced significantly larger amounts of the cytokines IL-6 (P ≤ 0.01), IL-10 (P ≤ 0.05) and TNF-α (P ≤ 0.01) than naïve 3xTg-AD mice and significantly larger amounts of IL-6 (P ≤ 0.05) and IL-10 (P ≤ 0.05) than infected Non-Tg mice. This evidence concerns the gene TNF and Alzheimer disease.