Further, IGROV-AF1 and SKOV3Trip2 cell lines were used to generate intraperitoneal tumor in mice, and treatments with either mouse specific Jagged 1 siRNA, human specific Jagged 1 siRNA or both siRNA significantly reduced tumor growth, which is explained that microvessel densities in tumors were inhibited by anti Jagged 1 siRNA treatments, thus Jagged 1 inhibition therapy induced anti-angiogenic effects [35]. Here, JAG1 is linked to neoplasm.