BRD2 and hyperandrogenism: Androgen excess in PCOS not only disturbs the balance between androgens, anti-Müllerian hormone (AMH) and FSH, but also contributes to ovarian tissue remodeling: stromal hyperplasia and rigidity, hypervascularity and inflammation [46] Androgen receptor are expressed in all cell types of the ovarian follicle, including the oocyte, granulosa and theca cells [47].