The significant differences on the levels of VEGF, placental growth factor (PlGF), angiopoietins, transforming growth factor beta (TGF-β), platelet-derived growth factor (PDGF), and basic fibroblast growth factor (bFGF) in the ovary, follicular fluid, and the circulation were found between patients with PCOS and normal women, suggesting that multiple pro-angiogenic factors are involved in abnormal angiogenesis in PCOS [7]. This evidence concerns the gene FGF2 and polycystic ovary syndrome.