NOTCH3 and cerebral arteriopathy with subcortical infarcts and leukoencephalopathy: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASI) is an autosomal dominant disease caused by rare mutations of the gene encoding the neurogenic locus notch homolog protein 3 (NOTCH 3 gene) located on chromosome 19p13 [95].