Recent results indicate that the role of CacyBP/SIP in signaling pathways involved in development of these cancers might be associated with dephosphorylation of a MAP kinase family member, ERK1/2 (Kilanczyk et al. 2011, 2012), followed by changes in the activity of Elk-1 and CREB-BDNF (Kilanczyk et al. 2009, 2015; Rosińska et al. 2016) and/or with participation in cellular response to oxidative stress (Topolska-Woś et al. 2015). The gene discussed is CACYBP; the disease is cancer.