On the basis of published data (Kilanczyk et al. 2009, 2011, 2012) and present results, it can be suggested that the role of CacyBP/SIP in signaling pathways engaged in development of cancers might be associated with dephosphorylation of MAP kinases and/or with its involvement in cellular response to oxidative stress (Topolska-Woś et al. 2015). This evidence concerns the gene CACYBP and cancer.