CDKN2A and pancreatic neoplasm: Genes that carry greater than a twofold increase in pancreatic cancer risk include APC, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, and STK11. Genes for which risk has not been established but for which studies suggest an elevated risk include ATM, BMPR1A, BRCA1, MEN1, MSH6, PALB2, PMS2, SMAD4, TP53, TSC1, and TSC2 and we recommend including these in the primary panel.