The genes associated with these other types of cancer syndromes (e.g., phosphatase and tensin homolog (PTEN), tumor protein p53 (TP53), breast cancer 1 and 2 (BRCA1/2),xeroderma pigmentosum (XP A-G)) are therefore acting as a lower-penetrance melanoma gene in the context of that syndrome [1]. This evidence concerns the gene PTEN and cancer.