ALM and mucosal melanoma have distinct genetic characteristics, such as less common BRAF and RAS mutations and a higher frequency of KIT mutations (10–20% for ALM, 15–20% for mucosal), compared to cutaneous melanomas (2%) [10–13] and a lower somatic mutational burden than that for SSM [14]. This evidence concerns the gene BRAF and acral lentiginous melanoma.