IL10RA and amyotrophic lateral sclerosis: Up-regulated interleukins in ALS are IL1B, the coding gene for interleukin 1B an important mediator of the inflam-matory response [45], interleukin 10 (encoded by IL10) which has pleiotropic effects down-regulating the expression of Th1 cytokines, MHC class II antigens and co-stimulating the production of several molecules by macrophages through the activation of IL10 receptor subunit α and subunit β (encoded by IL10RA and IL10RB, respectively) [46].