GABBR2, which codes for the metabotropic receptor component Gamma-Aminobutyric Acid Type B Receptor Subunit 2 and forms heterodimers with GABBR1, thus resulting in the formation of the G-protein coupled receptor for GABA [69], is also up-regulated in ALS. The gene discussed is GABBR1; the disease is amyotrophic lateral sclerosis.