IGHE and anaphylaxis: For example, patients with raised Ara h 2 sIgE do not necessarily have severe PA and can actually pass a peanut OFC122; 10% of patients with PFAS can have systemic reactions and 1% to 2% experience anaphylaxis.123, 124 The risk assessment of allergic patients depends on factors other than mere individual players of IgE-mediated food-induced allergic reactions (such as single allergens or epitopes, IgE, or basophils) and requires a holistic clinical evaluation of the patient.