The discrepancy in these findings could be due to the foods studied, as Gupta et al60 found the specific/total IgE ratio particularly useful for persistent food allergies (eg, peanut, tree nuts, shellfish, and seeds) and the study by Mehl et al61 focused on transient food allergies, namely, cow's milk, egg, and wheat allergies. This evidence concerns the gene IGHE and wheat allergic reaction.