Unlike NF-E2, the function of this newly-discovered transcription factor was not related to hematopoiesis; Nrf2-knockout mice did not show any obvious phenotype and were normally grown and fertile with no anemia [8,9,10], suggesting that Nrf2 regulates a different battery of genes from NF-E2. The gene discussed is NFE2L2; the disease is anemia (phenotype).