Finally, enhancing autophagy flux by the disaccharide trehalose in the brain of a transgenic P301S human tauopathy mouse model decreases the number of neurons containing tau inclusions, and reduces neuronal demise in layers I–III of the cerebral cortex and the pontine nucleus of the brainstem [56], indicating that autophagy may also participate in tau degradation. Here, MAPT is linked to tauopathy.