ATG7 and Alzheimer disease: In agreement, conditional ATG-7 deletion in cells of myeloid origin exacerbates inflammation in the hippocampus of fibrillar Aβ injected mice, concomitantly elevating caspase-1 and IL-1β levels [117], suggesting that the autophagy machinery may also regulate Aβ-elicited inflammasome activation in microglia in vivo in AD.