Moreover, the expression of Transcription Factor EB (TFEB), a major regulator of autophagy and lysosomal biogenesis [62], is restricted to the cytoplasm in SNpc DA neurons of PD patients, whereas it is found in the cytoplasm and the nucleus of control brains [63], further indicating that the autophagic process may be dysregulated. Here, TFEB is linked to Parkinson disease.