Furthermore, the circRNA-miRNA-mRNA interaction network of hsa_circ_0004277 from cytoscape analysis offered us several downstream gene-candidates, among which SH3GL2 and PPARGC1A were reported to be involved in several solid tumors, and SH2B3 especially as “a new leukemia predisposition gene” [28]. The gene discussed is SH2B3; the disease is leukemia.