Findings from the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) recently reported preliminary results of a shift to early stage disease and a reduction in cancer deaths on follow up to 14 years with multimodal ovarian cancer screening with serum CA125 interpreted using the Risk of Ovarian Cancer Algorithm (ROCA), transvaginal ultrasound, and clinical assessment. The gene discussed is MUC16; the disease is ovarian cancer.