CST3 and neoplasm: Furthermore, patients who died early due to aggressive disease or high tumor burden had a significantly higher median serum cystatin C level than the initial level of cystatin C for patients who achieved response after chemotherapy (7.792, range: 7.307–16.93 versus 5.456, range: 2.49–15.171 ng/mL, p = 0.013; Figure 7).