The amounts of CD3+CD56+ natural killer T (NKT) cells (as percentage of all lymphocytes) and activated CD45RA−CD25+CD3+CD4+ T helper cells (as percentage of all T helper cells) were increased significantly within SBM IR (SBM of immunologically restricted patients) when compared to SBM of controls and significantly within the FH IR when compared to FH of controls (Figure 1C,D). This evidence concerns the gene CD4 and familial hyperaldosteronism.