HP and obesity due to melanocortin 4 receptor deficiency: In a logistic regression model, higher zonulin levels were associated with increased risk to suffer from overweight (OR = 4.10 for highest compared with lowest quartile; 95% CI = 1.87–8.97), obesity (OR = 4.90 for highest compared with lowest quartile; 95% CI = 1.49–31.65), and hyperlipidemia (p for continuous values = 0.048), after adjustment for confounders (Table 6).