LCAT and hyperinsulinemic hypoglycemia, familial, 4: Increased lipid deposition has been demonstrated to have a role in progression of renal damage by several lines of evidence; first, there are a number of genetic abnormalities of lipid metabolism directly involving the kidney, such as Fabry’s disease [35], lecithin cholesterol acyltransferase deficiency [36], genetic and acquired lipodystrophy [37].