SQSTM1 and amyotrophic lateral sclerosis: In current study VCP, FUS, hnRNPA1 and TDP-43 were the cores of network in classical ALS (k = 4); ALS+FTD (k = 5) groups shared similar feature but included SQSTM-1 instead of hnRNPA1 and FUS (Fig 2A and 2B).