It has been known that 14-3-3 protein interacts with TDP-43 and SOD1 in ALS to modulate neurofilament light chain mRNA stability in G93A and A4T mSOD1 mice[85]; 14-3-3 protein was also found in lewy body in sALS[86]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.