There was no difference between TAC and sham rats in the residual uptake of [3H]-NE after specific blockade of the NET with DMI, demonstrating that the diminished cardiac elimination of [3H]-NE in TAC rats was entirely due to a reduced uptake via the NET, and not, for example, due to the extraneuronal NE transporter (uptake2 carrier) (Fig 1C). This evidence concerns the gene SLC6A2 and persistent truncus arteriosus.