AKT1 and Miyoshi myopathy: Figure 5a shows that duvelisib, but not CZC24832 and idelalisib, inhibits IL-6-induced AKT phosphorylation in serum-starved MM1s and primary MM samples. Figure 5b shows that duvelisib-induced inhibition is dose-dependent. To confirm these results we tested IL-6-induced activation of AKT in PI3Kδ KD, PI3Kγ KD and combined PI3Kδγ KD MM1s cells. Figure 5c shows that isolated PI3Kδ KD or isolated PI3Kγ KD failed to block IL-6-induced AKT activation; however combined PI3Kδγ KD completely blocks IL-6-induced AKT activation.