IL6 and cancer: The PI3K pathway contributes to the regulation of many cellular functions, including survival and proliferation, by catalysing the phosphorylation of phosphoinositide lipids.31 Aberrant PI3K pathway activation has been associated with several cancer types32, 33, 34 including MM and other haematological malignancies.11, 31, 35 Here we showed via Western blotting that the activation of this pathway is further upregulated in cell lines and primary samples when stimulated with the cytokine IL-6.