IL-6 secreted from the BMSCs in response to MM has been shown to play a key role in MM pathogenesis,36 acting as a growth factor for MM cells and promoting drug resistance in the bone marrow microenvironment.37, 38 In addition, we show that lentiviral targeting of both PI3Kδ/γ subunits inhibits IL-6-induced AKT activation, whereas singular δ and γ KD does not have a significant effect. This evidence concerns the gene IL6 and Miyoshi myopathy.