All muscular dystrophy hallmarks (degeneration/regeneration cycles, inflammatory response, fibrosis) were clearly visible in various 3-week-old dy3K/dy3K, dy3K/OPN and dy3K/GAL muscles, but not in osteopontin or galectin-3 knockout mice (Fig. 5a and b). The gene discussed is SPP1; the disease is muscular dystrophy.