Bortezomib has been found to trigger substantial accumulation of Noxa after 18 or 24 h in numerous melanoma cell lines (Fernández et al. 2005; Qin et al. 2005; Wolter et al. 2007; Reuland et al. 2012; Selimovic et al. 2013). Here, PMAIP1 is linked to melanoma.