MYC and neoplasm: In tumor cells however, the cellular levels of Myc become independent from such signaling and regulation, and the resulting exacerbated Myc function drives intracellular and extracellular transcription programs that allow tumors to grow and thrive (Soucek and Evan, 2002; Dang, 2012; Whitfield and Soucek, 2012; Conacci-Sorrell et al., 2014; Fletcher and Prochownik, 2015).