Similarly, folate nanoliposomes carrying siRNA targeting N-myc induce tumor cell apoptosis in a neuroblastoma model in vivo (Zhu et al., 2013), and lipid/calcium/phosphate nanoparticles combining c-myc siRNA and gemcitabine into a single nanovesicle were shown to inhibit lung tumor growth with little toxicity after systemic administration in xenograft models (Zhang et al., 2013). Here, MYCN is linked to neoplasm.