MYC and neoplasm: Myc synthetic lethality has been observed with various other targets in mouse tumor models, for example with ARK5 (Liu et al., 2012), PIM kinase (Horiuchi et al., 2016), microRNA-206 that acts by inhibiting MAP3K13 (Han et al., 2016), Aurora kinases (den Hollander et al., 2010; Yang et al., 2010), CHK1 (Murga et al., 2011; Ferrao et al., 2012), and MondoA (Carroll et al., 2015).