MCAM and metastatic melanoma: Both studies have been performed by using the Cell-Search Melanoma Kit (Veridex platform), which identifies double MCAM/MUC18/CD146-MCSP positive, double CD45-CD34 negative cells as CMCs.18,23,24,116 In particular, Khoja et al.20 indicated that 26% of metastatic melanoma patients have 2× CMCs at baseline and that median OS was shorter than those with <2 CMCs (2.6 versus 7.2 months, log-rank P<0.009).