Additionally, since rapalogs do not block mTORC1-mediated 4E-BP1 phosphorylation (Thr 37/46), cancer cells displaying a phospho-S6low/phospho-4E-BP1high pattern might be intrinsically resistant to rapalogs despite the presence of mTORC1 activity in these cells. This evidence concerns the gene EIF4EBP1 and cancer.