TNF and tuberculosis: To address the contribution of TNF derived from myeloid and T cells in protective immunity against CNS-TB, we intracerebrally challenged the mice with M. tuberculosis and compared disease progression in various cell-specific TNF-deficient mice, including myeloid specific (MN-TNF−/−), T-cell specific (T-TNF−/−), and TNF deficient in both myeloid and T-cells (MT-TNF−/−).