The immunological relevant targets of miR-212-5p are KLF4, which has been shown to be involved in the response of DCs to fungal infections (Czakai et al., 2016) and to be important for inflammatory immune response (Alder et al., 2008; Rosenzweig et al., 2013), and SPN, a surface molecule of various immune related cells, e.g., T lymphocytes, thymocytes, monocytes, and neutrophiles (Remold-O'Donnell et al., 1987). This evidence concerns the gene KLF4 and fungal infectious disease.