In the current meta-analysis, a significant association was detected in the whole population between TGF-β1 gene -509C/T polymorphism and CAD under allelic (OR: 1.130), recessive (OR: 1.390), dominant (OR: 0.857), homozygous (OR: 1.258), heterozygous (OR: 1.147), and additive genetic models (OR: 1.131). This evidence concerns the gene TGFB1 and coronary artery disorder.