PARP1 and neoplasm: This was associated with reduced cell survival following 6 Gy of IR, suggesting that previously reported interactions between PARP inhibitors and radiation sensitivity in tumor models (Veuger et al. 2003; Loser et al. 2010) potentially result from a complex interplay between altered DNA repair dynamics and increased engagement of the IFN pathway, which in turn might be modulated by PARP inhibition.