LIPA and coronary artery disorder: Instead, the risk genotype has been found to be associated with increased LIPA gene expression in several tissues and cell types, including whole blood, peripheral blood mononuclear cells, monocytes, liver, and adipose.27–30 Here, we present evidence that addresses this apparent contradiction and suggest that a coding single nucleotide polymorphism in the signal peptide of LAL, which is in high LD with the CAD lead variant, affects LAL trafficking to the lysosome and is the likely causal variant at this locus.